Berenson JR, Anderson KC, Audell RA, et al. Monoclonal gammopathy of undetermined significance: a consensus statement. Br J Haematol 2010;150:28–38.
Paraproteins are common in the elderly population and less than 1% per year will transform to a more serious B cell malignancy. In light of the low transformation rate, afflicted patients do not need to be referred to a haematologist. Rather, this guideline provides advice on the diagnosis, staging and follow-up of monoclonal gammopathy of undetermined significance, and raises awareness of the associated problems of peripheral neuropathy, thromboembolic disease and osteoporosis.
Coiffier B, Losic N, Ronn BB, et al. Pharmacokinetics and pharmacokinetic/pharmacodynamic associations of ofatumumab, a human monoclonal CD20 antibody, in patients with relapsed or refractory chronic lymphocytic leukaemia: a phase 1–2 study. Br J Haematol 2010;150:58–71.
Rituximab is a monoclonal antibody to the CD20 transmembrane protein, and it has significantly improved outcomes in...]]>