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J Clin Pathol doi:10.1136/jclinpath-2011-200360
  • Editorial

Editorial: MMP-2 and MMP-9 in lymph-node-positive bladder cancer

  1. Paul K Hegarty
  1. Correspondence to Dr Paul K Hegarty, Department of Urology, Guys Hospital, Great Maze Pond, London SE1 9RT, UK; paulhego{at}hotmail.com
  • Accepted 6 August 2011
  • Published Online First 24 March 2012

The paper by Seiler et al1 describes tissue microarrays on tissue taken from 150 patients with invasive bladder cancer. These patients were clinically node negative on preoperative staging, but were found to have nodal metastases on subsequent histopathological examination. Patients had not received neoadjuvant chemotherapy. The median lymph node yield of 27 is a surrogate for thorough lymphadenectomy and careful histopathological processing. The authors set out to study variation …

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