Wnt signalling pathway in the serrated neoplastic pathway of the colorectum: possible roles and epigenetic regulatory mechanisms
- Correspondence to Dr Xiangsheng Fu, Department of Gastroenterology, Affiliated Hospital of Luzhou Medical College, Taiping Street 25#, Region Jiangyang, Luzhou, Sichuan 646000, China;
Contributors XF drafted the paper. LL revised the manuscript. YP edited the paper. All three authors take responsibility for the content of the paper.
- Accepted 2 February 2012
- Published Online First 12 March 2012
The role of Wnt signalling in the serrated neoplastic pathway of colorectal tumourigenesis appears to be heterogeneous. Wnt pathway abnormalities contribute to the progression of at least a subset of traditional serrated adenomas of the colorectum, but may play a less active role in its pathogenesis compared with that in conventional adenoma-carcinoma. However, immunohistochemical studies of β-catenin in sessile serrated adenomas have shown wide variability, producing conflicting results on Wnt signalling activation in sessile serrated adenomas. DNA methylation, involving APC, SFRPs and mutated in colorectal cancer (MCC), may bridge the mutational gap of APC or β-catenin for activating Wnt signalling in serrated adenomas of the colorectum.
Competing interests None.
Provenance and peer review Not commissioned; externally peer reviewed.