Immune factors involved in the cervical immune response in the HIV/HPV co-infection
- Arthur S Estevez (arthursalomao{at}gmail.com)
- Gerard J Nuovo (nuovo-1{at}medctr.osu.edu)
- Beatriz Grinsztejn (gbeatriz{at}unisys.com.br)
- Aparecida Tristão (atristao{at}unisys.com.br)
- Fabio B Russomano (frussomano{at}superig.com.br)
- José R Lapa e Silva (jrlapa.ntg{at}terra.com.br)
- Multidisciplinary Laboratory, Clementino Fraga Filho Hospital, Federal University of Rio de Janeiro, Brazil
- Marcia P DeOliveira (marciapo{at}ioc.fiocruz.br)
Abstract
Introduction: Immune factors influencing progression of cervical intraepithelial neoplasia (CIN) cancer remain poorly defined.
Aim: This study investigates the expression of RANTES, MIP-1 α, COX-1, COX-2, STAT-3, TGF- RI, IL-10R, TNFα-RII and TLR-4 in the cervical immune response in the HIV/HPV co-infected women.
Methods: Cervical biopsies of 36 patients were assayed by immunohistochemistry, and the VENTANA System was used for HIV-nef detection.
Results: Cervices from HIV+ patients showed nef in cells mainly around blood vessels, showing a decreased expression of all but IL-10R and STAT-3 while RANTES (P= 0.02) was highly expressed in comparison to controls. COX-1 was decreased in the HIV/HPV (P= 0.017) and HPV infected patients (P= 0.015) compared to controls.
Conclusion: We suggest that RANTES in HIV/HPV co-infection could influence the development of CIN and progression to cervical cancer.
