Interpretation of clonality and X-chromosome inactivation assays urge attention
- 1Department of Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
- 2Department of Oral Surgery and Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
- Correspondence to Dr Carolina C Gomes, Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627, Belo Horizonte, Minas Gerais CEP 31270 901, Brazil; gomes.carolinac{at}gmail.com
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Contributors Both the authors contributed equally to this manuscript.
- Accepted 1 November 2011
- Published Online First 22 November 2011
- Clonality
- HUMARA
- clonal nature
- personalised medicine
- head and neck cancer
- molecular pathology
- oral pathology
- tumour biology
- salivary gland tumours
There is a huge debate on the clonal origin of solid tumours. Since clonality has strong implications in the molecular diagnosis used to characterise the mutations that are important in personalised medicine, we highlight two serious recurrent misinterpretation issues regarding clonality. First, monotypy in X-inactivation assays is being repeatedly interpreted as monoclonality. Second, it …
