Out of the darkness and into the light: bright field in situ hybridisation for delineation of ERBB2 (HER2) status in breast carcinoma

Table 2

Comparison of HER2 status using SISH and FISH methodologies

Reference	Sample size	No. of test sites	Concordance (%)†	κ coefficient*
Sinczak-Kuta61	63	1	NS	0.38
Dietel et al76	99	5	96.0	0.75
Carbone et al63	89	5	98.9	NS
Shousha et al77	53	1	94.0	NS
Collins et al78	230	2	99.6	NS
Bartlett et al79	45	7	96.0	NS

FISH, fluorescence in situ hybridisation; SISH, silver in situ hybridisation; NS, not specified.
↵* 95% confidence level unless otherwise specified, coefficients rounded to two decimal places.
↵† Weighted averages were calculated in some instances.

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Out of the darkness and into the light: bright field in situ hybridisation for delineation of ERBB2 (HER2) status in breast carcinoma

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