rss
J Clin Pathol 2009;62:731-734 doi:10.1136/jcp.2009.066449
  • Original article

Lupus anticoagulant: case-based external quality assessment

  1. A M H P van den Besselaar1,
  2. K M J Devreese2,
  3. P G de Groot3,
  4. A Castel4
  1. 1
    Department of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden, The Netherlands
  2. 2
    Coagulation Laboratory, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent, Belgium
  3. 3
    Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands
  4. 4
    Department of Clinical Chemistry, Bronovo Hospital, The Hague, The Netherlands
  1. A M H P van den Besselaar, Haemostasis and Thrombosis Department, C2-R, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands; a.m.h.p.van_den_besselaar{at}lumc.nl
  • Accepted 21 April 2009

Abstract

Aims: A model for presenting case histories with quality assessment material is to be developed for the Dutch external quality assessment (EQA) scheme for blood coagulation testing. The purpose of the present study was to assess the performance of clinical laboratories in case-based EQA using the case history of a patient suffering from lupus erythematosus of the skin.

Methods: Along with the case history, a freeze-dried plasma sample from the patient was distributed to the participants of the Dutch EQA scheme for blood coagulation testing. The participants were requested to report their coagulation test results, interpretation of the test results, and suggestions for further testing.

Results: The response rate was 65%. Tests for lupus anticoagulant were performed by 27% of the respondents and mixing experiments by 32%. The interpretation of the test results was heterogeneous but the presence of lupus anticoagulant was suggested by 54% of the respondents. A substantial number of respondents (23%) did not provide any interpretation. Only few participants followed the sequential steps for lupus anticoagulant identification recommended by the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis.

Conclusions: Case-based EQA is useful as an educational postanalytical tool. Several limitations were noted, and these included the limited volume of the sample, the different matrix of the freeze-dried sample compared with a fresh sample, and the time lag between the case history and the preparation of the freeze-dried sample.

Footnotes

  • Competing interests: None.

This Article

  1. Abstract
  2. Full text
  3. PDF

Responses

  1. Submit a response
  2. No responses published

Register for free content


Free trial
Individuals may register for a free 60 day online trial to all content.

Free archive
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

Don't forget to sign up for content alerts so you keep up to date with all the articles as they ar