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J Clin Pathol 62:685-689 doi:10.1136/jcp.2009.064451
  • Original article

Improved method for assessing iron stores in the bone marrow

Table 5 Mean levels of Log ferritin, sTfR and CRP for iron status categories using Gale’s and Intensive grading methods
Biochemical tests Gales’ grading method Intensive grading method
Normal Iron deficiency Normal Functional iron deficiency Iron stores deficiency Functional and iron stores deficiency
Log ferritin (μg/l)* Mean (SD) [n] 2.7 (0.5) [89] 1.8 (0.7) [61] 2.8 (0.5) [34] 2.6 (0.6) [44] 1.9 (0.7) [29] 2.1 (0.8) 9
95% CI 2.6 to 2.8 1.6 to 2.0 2.6 to 2.96 2.4 to 2.8 1.7 to 1.2 1.6 to 2.7
sTfR (μg/ml)† Mean (SD) [n] 11.8 (10.7) [156] 22.7 (15.9) [86] 12.5 (16.2) [56] 11.4 (6.0) [76] 21.7 (12.5) [44] 27.0 (28.3) 14
95% CI 10.1 to 13.5 19.4 to 26.1 8.1 to 17.0 10.0 to 12.7 18.0 to 25.4 12.2 to 41.9
CRP (mg/ml)‡ Mean (SD) [n] 122.0 (6.7) [156] 71.9 (8.5) [86] 99.8 (70.1) [56] 126.7 (85.6) [77] 71.9 (74.7) [45] 68.9 (64.9) 13
95% CI 108.7 to 135.2 55.2 to 88.7 81.5 to 118.2 107.6 to 145.8 50.0 to 93.7 33.6 to 104.2
  • *Normal >30 μg/l.

  • †Normal <8.3 μg/ml.

  • ‡Normal <10 mg/ml.

  • sTfR, soluble transferrin receptor; CRP, C-reactive protein.

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