Table 4 Roenigk classification system51
| Roenigk grade | Fatty change | Nuclear pleomorphism | Necroinflammatory damage | Fibrosis |
| I | Mild or none | Mild or none | Mild or none | None |
| II | Moderate or severe | Moderate or severe | Moderate or severe portal inflammation | None |
| IIIa | With or without | With or without | With or without | Mild |
| IIIb | With or without | With or without | With or without | Moderate or severe |
| IV | With or without | With or without | With or without | Cirrhosis |
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A score of IIIb or IV is an indication to discontinue the drug. Early detection and discontinuation of the drug is associated with a favourable outcome.
