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J Clin Pathol 2009;62:195-200 doi:10.1136/jcp.2008.058735
  • Demystified

RNA interference screening demystified

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  1. C J Lord,
  2. S A Martin,
  3. A Ashworth
  1. The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
  1. Dr C J Lord, The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK; Chris.Lord{at}icr.ac.uk
  • Accepted 15 December 2008
  • Published Online First 6 January 2009

Abstract

Genetic screens, where the effects of modifying gene function on cell behaviour are assessed in a systematic fashion, have for some time provided useful information to those interested in disease pathogenesis and treatment. Genetic screens exploiting the phenomenon of RNA interference (RNAi) are now becoming commonplace. This article explains the different RNAi screen formats and describes some of the applications of RNAi screening that may be pertinent to the research pathologist.

Footnotes

  • Competing interests: None.

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