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J Clin Pathol 61:428-437 doi:10.1136/jcp.2007.049387
  • Leading article

Inflammatory myofibroblastic tumours: where are we now?

Table 1 Clinical and pathological features to consider before diagnosing inflammatory myofibroblastic tumour (IMT)
Features that favour IMT Features that argue against IMT
Child or young adult Middle-aged or older adult
Mass in lung or soft tissue of abdomen, pelvis, or retroperitoneum Mass in skin or subcutis, lymph node, spleen, or bladder
Diffuse inflammatory infiltrate with prominent plasma cells Patchy, predominantly lymphocytic inflammatory infiltrate
Mild nuclear atypia including scattered ganglion-like cells Moderate to severe nuclear atypia with hyperchromasia
Low mitotic rate without atypical forms Atypical mitoses
ALK positivity by immunohistochemistry or ALK gene rearrangement Necrosis

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