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J Clin Pathol 61:1073-1082 doi:10.1136/jcp.2008.057950
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Hereditary breast cancer: from molecular pathology to tailored therapies

Table 3 Genomic regions differentially gained and lost in BRCA1 when compared with sporadic controls
Wessels et al83 Van Beers et al82 Jonsson et al81
Most frequent copy-number gains 3q 3pter-t22 1q42.12–q42.13
7p 3q13–q27 3q26.32–q26.33
8q 8p12–pcent 3q27.1–q27.33
10p 10pter–p12 7q36.1–q36.3
12p 16p 8q24.23–q24.3
16p 18p 10p15.3
17q 10p15.1–p14
Most frequent copy-number losses 3p 5cent–q23 4p15.32–p14
4p Q131.3
5q 4q32.1–q34
12q 5q11.2–q23.3
16p 8pter–p12
18q 13q13.3–q21.32
15q12–q13.1
15q15.3–q21.1
17p13.2–p12

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