Two cases of cytokeratin positivity in atypical fibroxanthoma
- 1Department of Dermatology, Drexel University College of Medicine, Philadelphia, Pennslyvania, USA
- 2Department of Dermatology, Division of Dermatopathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
- Correspondence to: C Bansal Drexel University College of Medicine, 2967 Schoolhouse Lane, Apt C-602A, Philadelphia, PA 19144, USA; cb59{at}drexel.edu
- Accepted 3 November 2006
- Published Online First 4 May 2007
Atypical fibroxanthoma (AFX) is a pleomorphic tumour, first described by Helwig in 1961.1 AFX was thought to be a superficial form of malignant fibrous histiocytoma, but some describe AFX as a reactive lesion that can be confused with pleomorphic carcinomas. Clinically, AFX presents as a 1–2 cm rapidly growing, dome-shaped, polypoid nodule or plaque which may crust or ulcerate.2 AFX is a low-grade sarcoma and is usually cured by excision; however, recurrence and rare metastases have been reported.3
Histological examination shows a dome-shaped …
