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J Clin Pathol 2007;60:433-435 doi:10.1136/jcp.2006.038646
  • Case report

Kikuchi’s disease displaying a t(2:16) chromosomal translocation

  1. Katherine E Robertson1,
  2. Peter D Forsyth2,
  3. Paul J Batstone3,
  4. David A Levison4,
  5. John R Goodlad5
  1. 1Division of Pathology and Neuroscience, Ninewells Hospital and Medical School University of Dundee, Dundee, UK
  2. 2Departments of Haematology and North of Scotland Blood Transfusion Centre, Raigmore Hospital, Inverness, UK
  3. 3Cytogeneticist Cytogenetics Unit, Department of Pathology, Raigmore Hospital, Inverness, UK
  4. 4Division of Pathology and Neuroscience, Ninewells Hospital and Medical School University of Dundee, Dundee, UK
  5. 5Department of Pathology, NHS Lothian—University Hospitals Division, Western General Infirmary, Edinburgh, UK
  1. Correspondence to:
    Dr K E Robertson
    Division of Pathology and Neuroscience, Ninewells Hospital and Medical School University of Dundee, Dundee DD1 9SY, UK; k.e.robertson{at}dundee.ac.uk
  • Accepted 29 August 2006

Abstract

Kikuchi’s disease is a rare self-limiting lymphoproliferative condition of unknown aetiology, characterised by acute or subacute necrotising lymphadenitis. It is a benign condition that can mimic malignant lymphoma. In this report, a case of Kikuchi’s disease associated with a chromosomal abnormality is described. This is the first report in the literature of such a case and it highlights an important learning point; benign lymphoproliferative conditions can be associated with chromosomal abnormalities that are more typically associated with malignant lymphoproliferative conditions such as malignant lymphoma. The report illustrates the necessity for interpreting cytogenetic data in the relevant clinical and histopathological context in a multidisciplinary setting to avoid misdiagnosis and inappropriate treatment.

Footnotes

  • Competing interests: None.

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