rss
J Clin Pathol 2007;60:307-310 doi:10.1136/jcp.2005.035717
  • Original article

Expression of peroxisome proliferator activated receptor γ and cyclo-oxygenase 2 in primary and recurrent ovarian carcinoma

  1. Sylvia Stadlmann1,
  2. Uwe Gueth2,
  3. Edward Wight2,*,
  4. Leoni A Kunz-Schughart3,
  5. Arndt Hartmann3,
  6. Gad Singer1,*
  1. 1Institute of Pathology, University Hospital Basel, Basel, Switzerland
  2. 2Department of Gynecology and Obstetrics, University Hospital Basel, Basel, Switzerland
  3. 3Institute of Pathology, University of Regensburg, Regensburg, Germany
  1. Correspondence to:
 PD Dr G Singer
 Institute of Pathology, University Hospital Basel, Schönbeinstrasse 40, CH-4031 Basel, Switzerland; gsinger{at}uhbs.ch
  • Accepted 23 February 2006
  • Published Online First 12 May 2006

Abstract

Aim: Peroxisome proliferator-activated receptor γ (PPARγ) has emerged as a potential therapeutic target in several types of cancer. In ovarian carcinomas, limited and conflicting data on PPARγ protein expression have been reported.

Methods: The immunoexpression of PPARγ and its putative target cyclo-oxygenase 2 (COX2) was investigated in tumour tissues from 80 patients with primary and corresponding recurrent ovarian serous carcinomas after conventional platinum-based chemotherapy.

Results: PPARγ expression was observed in 29% of primary and recurrent carcinomas. In the recurrent tumours, PPARγ expression inversely correlated with COX2 overexpression in both chemosensitive (p = 0.02) and chemoresistant (p = 0.04) carcinomas.

Conclusions: The data indicate that PPARγ may represent a potential target for second-line treatment in ovarian cancers.

Footnotes

  • Published Online First 12 May 2006

  • ↵* These authors have contributed equally to the work.

  • Funding: This study was supported by the Swiss Cancer League (Oncosuisse), grant number OCS 01506-02-2004.

  • Competing interests: None declared.

This Article

  1. Abstract
  2. Full text
  3. PDF
  4. All versions of this article:
    1. jcp.2005.035717v1
    2. 60/3/307 most recent

Responses

  1. Submit a response
  2. No responses published

Register for free content

The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.