Immunohistochemical expression of T-cell transcription factors (TFs) in reactive lymphoid cells in tissues involved by Hodgkin’s lymphoma (HL)
| HL subtype | % Positive cells | T-bet | GATA3 | c-Maf | |||
|---|---|---|---|---|---|---|---|
| Cases/total | Intensity | Cases/total | Intensity | Cases/total | Intensity | ||
| NLPHL* | <10 | 5/6 | + | 7/7 | + | ||
| 10–25 | 3/6 | ++ | |||||
| 25–50 | 1/6 | +++ | 2/6 | +++ | |||
| 50–75 | 1/6 | +++ | |||||
| >75 | |||||||
| CHL† | <10 | 2/16 | + | 5/12 | + | 1/13 | + |
| 10–25 | 5/12 | ++ | 8/13 | + | |||
| 25–50 | 3/16 | ++ | 2/12 | ++ | 3/13 | ++ | |
| 50–75 | 7/16 | +++ | |||||
| >75 | 4/16 | +++ | 1/13 | ++ | |||
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NLPHL, nodular lymphocyte predominance type of Hodgkin’s lymphoma; CHL, classical Hodgkin’s lymphoma.
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+, weakly positive; ++, moderately positive; +++, strongly positive.
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Percentages refer to the percentage of immunoreactive cells relative to all infiltrating cells.
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*Most rosetting cells in NLPHL cases were moderately or strongly c-Maf+.
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†There was no clear difference among different subsets of CHL according to number of positive cells, distribution or intensity of T-cell TF expression.
