Comparative genomic hybridisation in malignant deciduoid mesothelioma
- A Scattone1,
- A Pennella2,
- M Gentile3,
- M Musti4,
- P Nazzaro5,
- A L Buonadonna3,
- A Marzullo1,
- D Cavone4,
- L Pollice1,
- G Serio1
- 1Department of Pathology, Medical School, University of Bari, Bari, Italy
- 2Department of Surgery and Pathology, Medical School, University of Foggia, Foggia, Italy
- 3Medical Genetics, De Bellis IRCCS Hospital, Castellana Grotte (Bari), Bari
- 4Department of Internal Medicine and Public Medicine, Industrial Medicine, Medical School, University of Bari
- 5Department of Clinical Methodology, Medical School, University of Bari
- Correspondence to: Dr G Serio Department of Pathology, Medical School, University of Bari, 11 G Cesare Square, 70124 Bari, Italy; g.serio{at}anatopat.uniba.it
- Accepted 23 November 2005
- Published Online First 28 March 2006
Abstract
Background: Malignant deciduoid mesothelioma is a rare variant of epithelioid mesothelioma. This tumour generally has poor prognosis, and can be asbestos related.
Aim: To identify peculiar genetic changes responsible for critical phases in pathogenesis of malignant deciduoid mesothelioma and their prognostic relevance.
Methods: Comparative genomic hybridisation was carried out in six cases of malignant pleural deciduoid mesothelioma, four sporadic and two familial. All cases were found to be asbestos related. Four patients died during follow-up and the mean survival was 29.5 (SD 14.2, range 12–43) months.
Results: Genetic abnormalities were found in all the tumour tissues, the most frequent being chromosomal gains at 1p, 12q, 17, 8q, 19 and 20 and losses at 13q, 6q and 9p. Survival was found to be longer in those patients who presented a smaller number of losses (≤2) in the tumorous chromosomes.
Conclusions: Although numerous genetic changes are presented by deciduoid mesotheliomas, certain chromosomal regions are preferentially affected. The clinical outcome for this mesothelioma subtype is predicted by the number of losses.
Footnotes
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Published Online First 28 March 2006
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Competing interests: None declared.
