Table 1
Medline listed peer reviewed reports since 1995 examining the role of fine needle aspiration cytology in diagnosis of phyllodes tumour
| Authors | Year | Focus of study | n (PT) | Controls | Blinding | % PT with definite diagnosis on FNAC | Comments |
|---|---|---|---|---|---|---|---|
| FA, fibroadenoma; FNAC, fine needle aspiration cytology; PT, phylloides tumour. | |||||||
| Shabalova et al60 | 1997 | Diagnose benign and borderline PT | 19 | Yes (FA, fibrocystic disease, and carcinoma) | No | 32% | Atypical changes in large proportion. Advise care in cytopathological diagnosis if myxoid stromal component |
| Shabb et al61 | 1997 | Elucidate features of PT | 8 | No | No | N/A | Discussion relates to distinguishing PT from FA. Advise multiple aspirates and thin smears |
| Deen et al62 | 1999 | Distinguish FA and PT | 19 | Yes (FA) | No | N/A | Overlapping spectrum. Suggest intermediate group of uncertain malignant potential |
| Bhattarai et al63 | 2000 | Determine PT subtypes | 80 | No | Yes | 71.3% | Good cytohistological correlation in 81%. Advise multiple site aspiration |
| Krishnamurthy et al64 | 2000 | Distinguish FA and PT | 12 | Yes (FA) | No | 33.3% | Long spindle nuclei comprising ⩾30% of dispersed stromal cells diagnostic of phyllodes tumour (10–30% = indeterminate) |
| Scolyer et al65 | 2001 | Distinguish FA and PT | 8 | Yes (FA) | Yes | 62.5% | Hypercellular stromal fragments most useful feature – presence should raise possibility of PT |
| Badhe et al66 | 2002 | Distinguish FA and PT and determine subtypes | 9 | Yes (FA) | Yes | 77% | Semiquantitative team approach improved diagnosis of FA |
| Jayaram et al67 | 2002 | Diagnose PT and determine subtypes | 28 | No | No | 71.4% | Criteria for diagnosis of benign PT = at least two of large stromal fragments, hypercellular stromal fragments, and moderate to large numbers of dissociated stromal cells |
| Shimizu et al68 | 2002 | Distinguish FA and benign PT | 18 | Yes (FA) | No | N/A | Size and shape of epithelial clusters provide additional clues (longer than 1 mm, wavy or folded in phyllodes tumour) |
| Totals | 201 | 99/156 = 63% | Indeterminate results excluded | ||||
