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J Clin Pathol 2006;59:1127-1132 doi:10.1136/jcp.2005.031120
  • Review

Alveolar soft-part sarcoma: a review and update

  1. A L Folpe1,
  2. A T Deyrup2
  1. 1Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Minnesota, USA
  2. 2Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, Georgia, USA
  1. Correspondence to:
    A L Folpe
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA; folpe.andrew{at}mayo.edu
  • Accepted 25 January 2006

Abstract

Alveolar soft-part sarcoma (ASPS) is a rare, distinctive sarcoma, typically occurring in young patients. Although it displays a relatively indolent clinical course, the ultimate prognosis is poor and is often characterised by late metastases. Recently, our understanding of the genetic events underlying the pathogenesis of ASPS has greatly increased. The historical, histopathological, ultrastructural, immunohistochemical and genetic aspects of ASPS are reviewed in this article.

Footnotes

  • Competing interests: None declared.

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