Diagnosis and grading of dysplasia in Barrett’s oesophagus

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Figure 7

Medium and (A) high-power view of an area of Barrett’s oesophagus (BO) showing basal crypt dysplasia-like atypia with surface maturation. In this focus, the basal portion of the crypt shows dysplastic-appearing cells characterised by nuclear enlargement, stratification, loss of polarity and a focal gland in gland pattern. Mitoses are readily identified. The superficial portion of the crypts, however, shows evidence of surface maturation characterised by a decrease in the size of nuclei, less stratification and progressive acquisition of mucin in the cytoplasm of cells on the surface BO.

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Diagnosis and grading of dysplasia in Barrett’s oesophagus

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