- My approach
Diagnosis and grading of dysplasia in Barrett’s oesophagus
(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.
(A) In contrast with low-grade dysplasia (LGD), high-grade dysplasia (HGD) shows crowded crypts with more severe nuclear stratification. The nuclei reach the luminal surface in the deeper portions of the crypts. In addition, there is mild architectural distortion. On high-power view (B), the nuclei have a slightly more open chromatin pattern with prominent, sometimes multiple, nucleoli and a more marked loss of cell polarity. The nuclear/cytoplasmic ratio of HGD is markedly increased compared with LGD.
Register for free content
Free trial
Individuals may register for a free 60 day online trial to all content.
Free archive
The full back archive is now available for all BMJ Journals.
Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have
access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006
right back to volume 1 issue 1. Register here to access the free archive
of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they ar
