Table 4
Possible mechanisms of disease in CFS based on three gene expression studies, each on patients with CFS and normal controls
| Mechanism | Present study | Powell and colleagues4 | Vernon and colleagues5 |
|---|---|---|---|
| CSF, chronic fatigue syndrome; qPCR, quantitative polymerase chain reaction. | |||
| Microarray (9522 genes)/qPCR; 25 CFS; 25 normal | Differential display/qPCR; 7 CFS; 4 normal | Filter array (1764 genes); 5 CFS; 17 normal | |
| T cell activation | CD2BP2, IL-10RA | Moesin, CTSC | ITGA, NFATC3 |
| Immune response | PRKCL1 | TNF, MAIL | IL-8, CMRF35, ICAM2, ITGB, IER2, PLA2G2A, LCP-1, PRKCL |
| Neurone | PRKCL1, GSN, KHSRP, NTE, GABARAPL1 | HD, PRKCL, ataxin, ADRA2A, DCTN1 | |
| Mitochondrion | EIF4G1, EIF2B4, MRPL23 | SLC25A16, MCFP | |
| Skeletal muscle | GSN | DCTN1 | |
| Thyroid | GSN | THRAP2, SLC25A16 | GDC |
| Cell cycle | ANAPC11 | MAD1L1 | |
| Apoptosis | PDCD2 | ||
| Transcription | POLR2G, BRMS1 | RCOR3, POLR1B | |
| Peroxisome | ABCD4, PEX16 | ||
