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J Clin Pathol 58:815-819 doi:10.1136/jcp.2004.023911
  • Original article

Granulomatous reactions cause symptoms or clinically imitate treatment resistance in small lymphocytic lymphoma/chronic lymphocytic leukaemia more frequently than in other non-Hodgkin lymphomas

Table 3

 Histological, histochemical, and immunohistochemical findings

Case Granuloma location Histology CD4/CD8* Ziehl-Neelsen PAS Fite-Faraco TBC-PCR
*Within the granulomas.
BM, bone marrow; CLL, small lymphocytic lymphoma/chronic lymphocytic leukaemia; LN, lymph node; PAS, periodic acid schiff; PCR, polymerase chain reaction; TBC, tuberculosis.
1 BM Microgranuloma, no giant cells; CLL 1/1 Negative Negative Negative Negative
2 LN Circumscribed granulomas, epithelioid and Langhans giant cells; CLL 5/1 Negative Negative Negative Negative
3 BM Circumscribed granulomas, epithelioid cells, no giant cells; CLL 10/1 Negative Negative Negative Negative
4 LN Necrotising granulomas, epithelioid and Langhans giant cells; CLL 2/1 Positive Negative Negative Positive
5 LN Large granulomas, foamy macrophages; CLL No T cells Positive Positive Positive Negative

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