Table 4
MSI in gastric advanced precancerous lesions
| First author | Adenoma/Dysplasia/NiN | MSI | Microsatellite markers | ||
|---|---|---|---|---|---|
| Without coexisting GC | With coexisting GC | MSI-L (%) | MSI-H (%) | ||
| The different histology/nomenclature categories applied by the authors are reported. MSI-L and MSI-H are distinguished according to the criteria adopted by each author. | |||||
| Ad, adenoma; GC, gastric cancer; GED, gastric epithelial dysplasia; HG, high grade; LG, low grade; MSI, microsatellite instability; MSI-H/L, high/low frequency microsatellite instability; NiN, non-invasive neoplasia. | |||||
| Abraham (2003)21 | 12 LG-GED | 0 | 1 (8) | BAT25, BAT26, D2S123, D5S346,D17S250 | |
| 4 HG-GED | 2 HG-GED | 0 | 2 (33) | ||
| Jin (2001)25 | 20 LG-NiN | 0% | 1 (5) | BAT26, D2S115, D4S404, D5S178, IL9, D6S265, D7S490, D11S900, MYH6, TP53, D17S1176, D18S46, D21S1407 | |
| 32 HG-NiN | 4 (12.5) | 6 (18.7) | |||
| Lee (2002)22 | 75 Ad | 7 (9) | 2 (3) | BAT26, D2S123, D5S346, D17S250, BAT25 | |
| 35 Ad | 3 (9) | 6 (17) | |||
| Chang (2002)23 | 67 Ad | 7 (10.4) | BAT26 | ||
| 65 Ad | 8 (12.3) | ||||
| Endoh (2000)14 | 24 | 8 (33) | BAT26 | ||
| Ohmura (2000)42 | 13 LG | ? | 1 (7.7) | D2S115, D4S404, D5S178, IL9, D6S265, D7S490, D11S900, MYH6, TP53, D17S1176, D18S46, D21S1407 | |
| 20 HG | ? | 8 (40) | |||
| Kim (2000)16 | 41 LG-Ad | 9 (22) | 50 loci | ||
| 22 HG-Ad | 4 (18) | ||||
| Isogaki (1999)24 | 13 | 1 (7.6) | D1S116, D2S136, D6S87, D10S197, TP53 | ||
| 37 | 6 (16.2) | ||||
| Semba (1996)8 | 12 | 5 (42) | D2S123, D2S110, D2S136, D3S1O67, D5S5O5, D7S486, D11S29, TP53, D17S855 | ||
