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J Clin Pathol 58:705-709 doi:10.1136/jcp.2004.025239
  • Original article

Pathological diagnosis of columnar cell lesions of the breast: are there issues of reproducibility?

Table 4

 Repeated images/lesions, their proffered diagnoses by AH, and the intraobserver agreement of pathologists in both exercises

Repeated images (according to sequence of appearance in the set) No. of pathologists with different answers in the 1st exercise No. of pathologists with different answers in the 2nd exercise Comments
arch, architectural; CCC, columnar cell change; CCH, columnar cell hyperplasia; cytol, cytological; DCIS, ductal carcinoma in situ.
Images 1 and 13 (CCC) 2 (CCC to CCC with cytol atypia; CCC to CCH) 2 (CCH to CCC with cytol atypia; CCC to CCH) Low and high power magnification of the same lesion
Images 4, 15, 26 (DCIS) 1 (DCIS to CCC with cytol atypia) 0 Identical images
Images 5 and 11 (CCC) 2 (not CCC/DCIS to CCC; not CCC/DCIS to CCC with arch atypia) 0 Low and high magnification of the same lesion
Images 9, 10, 12 (CCC with arch atypia for image 9, CCC with cytol atypia for images 10 and 12) 7 (see text) 5 (see text) Low, medium, and high magnification of the same lesion
Images 19 and 36 (CCH) 1 (CCH to CCC with cytol atypia) 0 Identical images
Images 25 and 32 (CCC) 0 3 (CCC to CCC with cytol atypia; CCH to CCC with cytol atypia; not CCC/DCIS to CCC) Identical images
Images 34 and 35 (DCIS) 0 0 Low and high power magnification

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