Table 11
Factors predicting HER-2/neu overexpression* in ER+ breast cancers (n = 1104): multivariate analysis
| Odds ratio† (95% CI) | p Value | |
|---|---|---|
| *HER-2/neu was defined as negative when the DAKO score was 0, 1+, or 2+ and positive when 3+; †odds ratio adjusted for all variables in table; ‡ER and PR were defined as negative when the H score was ⩽50, and positive when 51–300. | ||
| CI, confidence interval; ER, oestrogen receptor; PR, progesterone receptor. | ||
| PR expression‡ (negative v positive) | 2.01 (1.22–3.32) | 0.006 |
| Tumour grade (grade 3 v 1–2) | 4.27 (2.62 to 6.97) | <0.001 |
| Tumour size (>20 v ⩽20 mm) | – | 0.300 |
| Lymph node (positive v negative) | – | 0.692 |
| Age (⩽50 v >50 years) | – | 0.088 |
