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J Clin Pathol 58:611-616 doi:10.1136/jcp.2004.022772
  • Original article

Association between tumour characteristics and HER-2/neu by immunohistochemistry in 1362 women with primary operable breast cancer

Table 1

 Clinicopathological features (n = 1362)

N %
*HER-2/neu was defined as negative when the DAKO score was 0 or 1+, and positive when 2+ or 3+; †HER-2/neu was defined as negative when the DAKO score was 0, 1+, or 2+, and positive when 3+; ‡ER and PR were defined as negative when the H score was ⩽50, and positive when 51–300.
ER, oestrogen receptor; PR, progesterone receptor.
HER-2/neu status*
    Negative (score 0, 1+) 1121 82.3%
    Positive (score 2+, 3+) 241 17.7%
HER-2/neu status†
    Negative (score 0, 1+, 2+) 1213 89.1%
    Positive (score 3+) 149 10.9%
ER expression‡
    Negative 258 18.9%
    Positive 1104 81.1%
PR expression‡
    Negative 488 35.8%
    Positive 874 64.2%
Tumour grade
    1–2 828 60.8%
    3 534 39.2%
Tumour size
    ⩽20 mm 721 52.9%
    >20 mm 641 47.1%
Lymph node
    Negative 880 64.6%
    Positive 482 35.4%
Age
    ⩽50 years 429 31.5%
    >50 years 933 68.5%
Total 1362 100.0%

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