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J Clin Pathol 58:509-514 doi:10.1136/jcp.2004.020347
  • Original article

Expression and gene amplification of primary (A, B1, D1, D3, and E) and secondary (C and H) cyclins in colon adenocarcinomas and correlation with patient outcome

Table 6

 Relation between various clinicopathological parameters and survival

Log rank test Cox regression test*
p Value p Value HR 95% CI
*Including only parameters with significance in the univariate test and adjusted for age; †all tumours were immunopositive for cyclin H.
Cyclin A 0.015 0.044 0.57 0.33 to 0.98
Cyclin B1 0.557
Cyclin C 0.069
Cyclin D1 0.420
Cyclin D3 0.162
Cyclin E 0.070
Cyclin H –†
CCNA amplification 0.440
CCNB1 amplification 0.623
CCNC amplification 0.019 0.049 1.72 1.00 to 2.94
CCND1 amplification 0.280
CCND3 amplification 0.971
CCNE amplification 0.611
CCNH amplification 0.468
Tumour differentiation 0.044 0.062 0.51 0.25 to 1.04
Dukes stage <0.001 <0.001 4.89 3.39 to 7.10

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