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J Clin Pathol 58:172-177 doi:10.1136/jcp.2004.019885
  • Original article

Differential prognostic impact of hypoxia induced and diffuse HIF-1α expression in invasive breast cancer

Table 3

 Disease free survival analysis of invasive breast cancer patients (n = 166) according to HIF-1α positivity and staining pattern

Cutoff n Recurrence p Value* HR 95% CI
*Log rank test.
CI, confidence interval; HIF-1α, hypoxia inducible factor 1α; HR, hazard ratio.
HIF-1α ⩽1% 100 17% 1.00 1.18 to 4.202
>1% 66 33% 0.01 2.23
Staining pattern Diffuse 51 31% 0.04 2.03 1.025 to 4.019
Necrotic 15 40% 0.02 3.05 1.200 to 7.741

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