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J Clin Pathol 58:1206-1210 doi:10.1136/jcp.2005.026559
  • Original article

Grading melanocytic dysplasia in paraffin wax embedded tissue by the nucleic acid index

Table 1

 Nucleic acid index of melanocytic lesions

Mean (SD) NAI Diagnosis, site Breslow thickness Mitotic index (/10 HPF)
*Estimated because the lesion occupied only 2 HPF.
HPF, high power field; NAI, nucleic acid index; N/D, not determined.
1.2 (0.3) Malignant melanoma, foot 7.6 8
1.4 (0.1) Malignant melanoma, back 6 10
1.5 (0.2) Malignant melanoma, eyebrow 4.0 10§
1.6 (0.5) Malignant melanoma, back 2.6 30
1.6 (0.1) Metastatic melanoma, axilla N/D N/D
1.7 (0.1) Malignant melanoma, knee 7.0 5
1.7 (0.2) Melanoma in situ, ear N/D N/D
2.2 (0.3) Malignant melanoma, ankle 0.53 5
2.2 (0.4) Malignant melanoma, head 2.0 5
2.7 (0.2) Malignant melanoma, back 4.4 3
2.7 (0.7) Malignant melanoma, chest 1.87 5*
2.7 (0.3) Malignant melanoma, breast 0.34 5*
2.8 (0.6) Malignant melanoma, back 1.2 5
2.9 (0.5) Dysplastic naevus, abdomen N/D N/D
3.5 (0.4) Benign naevus, head N/D N/D
3.6 (0.5) Dysplastic naevus, groin N/D N/D
4.2 (0.3) Dysplastic naevus, breast N/D N/D
4.3 (0.5) Benign naevus, neck N/D N/D
4.6 (0.3) Dysplastic naevus, not provided N/D N/D
5.1 (0.5) Benign naevus, axilla N/D N/D
5.8 (0.8) Dysplastic naevus, back N/D N/D
N/D Seven benign naevi N/D N/D

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