Table 2
Virological and immunophenotypic characteristics of KSHV/HHV-8 associated solid lymphomas
| Case 1 | Case 2 | |
|---|---|---|
| +, almost all neoplastic cells positive; +/−, most neoplastic cells positive; −/+, minority of neoplastic cells positive; −*, few neoplastic cells positive; −, all neoplastic cells negative; NE, not evaluable. | ||
| AQP3, aquaporin 3; CIgG, cytoplasmic IgG; CLA, common leucocyte antigen; EBER, Epstein-Barr virus encoded small non-coding RNA; EBNA-1, Epstein-Barr virus nuclear antigen 1; EMA, epithelial membrane antigen; HHV-8, human herpesvirus type 8; IHC, immunohistochemistry; ISH, in situ hybridisation; KSHV, Kaposi sarcoma associated herpesvirus; ORF, open reading fragment; PCR, polymerase chain reaction; SELPLG, selectin P ligand; syn-1, syndecan 1; VEGF, vascular endothelial growth factor. | ||
| KSHV (IHC) | ORF73+ | ORF73+ |
| vIL-6− | vIL-6+ | |
| KSHV (PCR) | KS330+ | KS330+ |
| ORF72+ | ORF72+ | |
| ORF9-3+ | ORF9-3− | |
| EBER (ISH) | − | + |
| EBNA-1 (PCR) | − | + |
| LMP1 (IHC) | − | − |
| CLA/CD45 | − | −/+ |
| EMA | + | −* |
| MUM1/IRF4 | + | + |
| CD138/syn-1 | + | −/+ |
| VS38c | −/+ | + |
| CD30 | −/+ | − |
| ALK (ALK1) | − | − |
| CD20 | − | − |
| CD40 | − | − |
| CD79a | − | − |
| CD3 | −/+ | − |
| CD5 | − | − |
| CD43 | −/+ | −/+ |
| CD45RO | − | − |
| CD10 | − | − |
| Ki-67/MIB1 | + | + |
| κ/λ chain | − | − |
| CIgG | + | + |
| CD15 | − | − |
| CD68 | − | − |
| S100 | − | − |
| Keratin (AE1/AE3) | − | − |
| Keratin (MNF116) | − | − |
| Granzyme A | −/+ | −* |
| AQP3 | −* | + |
| SELPLG | + | + |
| VEGF | + | + |
