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J Clin Pathol 58:1033-1038 doi:10.1136/jcp.2005.026260
  • Original article

Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress

Table 6

 MIB1 proliferation index in fibroblast at the invading tumour front and its association with parameters indicative of hypoxic stress and acidity

MIB1 proliferation index in fibroblasts
Low High p Value
HIF1α, hypoxia inducible factor-1α; LDH, lactate dehydrogenase; VEGF, vascular endothelial growth factor.
VEGF
    Low 60 46 0.07
    High 18 26
HIF1α
    Low 56 36 0.006
    High 22 36
LDH5
    Low 30 17 0.05
    High 48 55

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