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J Clin Pathol 57:973-979 doi:10.1136/jcp.2003.015875
  • Original article

Colonic IgA producing cells and macrophages are reduced in recurrent and non-recurrent Clostridiumdifficile associated diarrhoea

Table 1

 Details of patients studied

Age (years) Sex Diarrhoea duration(days) Diarrhoea frequency (stool/day) Temp (°C) WBC(×109/l) CRP(mg/l) Serum IgA Serum IgM Serum IgG
Group A, controls; group B, CDAD; groups C and D, PMC. Patients with PMC had significantly higher WBC and CRP than controls (group A; *p<0.05) but not the CDAD group with no or minimal inflammation (group B). The duration of diarrhoea was longer in patients with PMC than both controls (group A) and the CDAD group with absent or minimal inflammation (group B) (**p<0.05). There was no significant difference in age, sex, diarrhoea frequency, or temperature between the groups. Results are expressed as mean (SEM).
CDAD, Clostridium difficile associated diarrhoea; CRP, C reactive protein; PMC, pseudomembranous colitis; WBC, white blood cell count.
Group A 76 (2.7) 6M 6F 6 (2) 5.7 (1) 36 (0.2) 12 (1.7) 68 (29) 1.59 (0.35) 0.89 (0.39) 7.01(1)
Group B 64 (10) 4M 2F 6.4 (1.7) 6.7 (1) 37 (0.2) 14 (4) 81 (34) 3.01 (1) 0.73 (0.21) 10.5 (2.6)
Groups C/D 82 (2.5) 6M 4F 16.6 (5)** 6.3 (1) 37 (0.2) 21 (2)* 129 (24)* 2.41 (0.51) 0.70 (22) 7.97 (1.24)

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