Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HIF-1α) and the HIF-1α target gene DEC1, but not lymph node metastasis in primary human breast carcinomas

Table 1

Comparison of the expression of angiogenic ligand VEGF-D protein and the clinicopathological variables

	VEGF-D negative	VEGF-D positive	p Value
*Significant.
EGFR, epidermal growth factor receptor; ER, oestrogen receptor; HIF, hypoxia inducible factor; VEGF, vascular endothelial growth factor.
Total no of patients	75	132
Age
<50	19	41	0.38
⩾50	56	91
Nodal status
Negative	44	84	0.48
Positive	31	48
Tumour size
⩽2 cm	47	87	0.64
>2 cm	28	45
Grade
I	15	32	0.12
II	22	32
III	10	33
ER
Negative	19	46	0.16
Positive	56	86
EGFR
Negative	31	50	0.64
Positive	42	78
HIF-1α
Negative	61	93	0.03*
Positive	6	25
DEC1
Negative	33	26	0.0001*
Positive	26	93

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Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HIF-1α) and the HIF-1α target gene DEC1, but not lymph node metastasis in primary human breast carcinomas

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