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J Clin Pathol 57:712-716 doi:10.1136/jcp.2004.016030
  • Original article

The loss of calretinin expression indicates aganglionosis in Hirschsprung’s disease

Table 1

 Calretinin, S100, NSE, and c-kit expression in different areas of the colon in patients with HD

Calretinin staining* S100 staining in nerve fibres NSE staining in ganglionic cells Abnormal c-kit staining
Ganglionic cells Nerve fibres
*Includes submucosal and myenteric plexus.
Hirschsprung’s disease; NSE, neurone specific enolase.
Ganglionic segment 24/24 24/24 24/24 24/24 4/24
Aganglionic segment No ganglion cells 0/17 17/17 0/17 17/17
Transitional zone 10/13 12/13 13/13 12/13 10/13

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