Table 1
Overview of different studies on the prognostic value of mitotic activity in invasive breast cancer
| First author | Ref | P/R | N | Subgroup | Overall survival | Significance | Independent value |
|---|---|---|---|---|---|---|---|
| Not all these studies used independent patient groups. | |||||||
| LN, lymph node; NS, not significant; P, prospective, R, retrospective. | |||||||
| Aaltomaa | 121 | R | 293 | LN– | 0.005 | – | Yes |
| 121 | R | 224 | LN+ | 0.004 | – | Yes | |
| 122 | R | 106 | All | <0.001 | <0.001 | Yes | |
| 119 | R | 281 | LN– | 0.0115 | 0.0007 | Yes | |
| 118 | R | 688 | All | <0.0001 | <0.0001 | Yes | |
| 120 | R | 611 | All | <0.001 | <0.001 | Yes | |
| Baak | 104 | R | 271 | Ductal | – | <0.001 | Yes |
| 105 | R | 82 | Ductal | – | 0.0254 | Yes | |
| 159 | P | 576 | LN–, <55 | <0.0001 | <0.0001 | Yes | |
| Barbareschi | 124 | R | 178 | LN– | 0.03 | – | No |
| Biesterfeld | 125 | R | 104 | All | – | <0.0001 | Yes |
| 152 | R | 108 | LN+ | – | 0.0093 | Yes | |
| Bos | 107 | R | 153 | All | 0.046 | 0.017 | Yes |
| Chen | 155 | R | 255 | LN– | NS | NS | No |
| Clahsen | 82 | R | 441 | LN– | <0.01 | – | – |
| Clayton | 127 | R | 378 | LN– | – | <0.0001 | Yes |
| 126 | R | 399 | LN+ | – | <0.0001 | Yes | |
| Collan | 108 | R | 120 | All | – | 0.001 | Yes |
| Colpaert | 128 | R | 104 | LN– | <0.0001 | – | No |
| Jong | 13 | R | 112 | All | – | 0.0009 | Yes |
| Eskelinen | 129 | R | 216 | All | 0.01 | – | Yes |
| Groenendijk | 4 | R | 387 | All | <0.0001 | – | – |
| Ikpatt | 130 | R | 300 | All | – | <0.0001 | Yes |
| Jannink | 112 | R | 186 | All | – | <0.001 | Yes |
| 113 | R | 189 | All | – | <0.001 | Yes | |
| Joensuu | 131 | R | 311 | All | – | <0.0001 | – |
| Kato | 156 | R | 70 | LN– | – | NS | No |
| 132 | R | 422 | All | <0.0001 | <0.0001 | Yes | |
| Keshgegian | 133 | R | 126 | All | 0.0003 | – | – |
| Kronqvist | 135 | R | 364 | All | <0.0001 | – | Yes |
| 134 | R | 202 | All | – | 0.0001 | Yes | |
| Ladekarl | 138 | R | 71 | Ductal | – | 0.1 | Yes |
| 137 | R | 98 | LN– | – | 0.0005 | Yes | |
| Laroye | 157 | R | 76 | All | – | NS | Yes |
| Le Doussal | 95 | R | 1262 | Ductal | <0.0001 | 0.002 | Yes |
| Linden | 160 | P | 195 | All | 0.001 | – | Yes |
| 114 | R | 156 | All | 0.001 | 0.005 | Yes | |
| Lipponen | 139 | R | 111 | All | 0.001 | 0.001 | Yes |
| 141 | R | 363 | All | 0.004 | 0.001 | Yes | |
| 140 | R | 202 | All | 0.012 | – | Yes | |
| Liu | 142 | R | 791 | All | <0.0001 | <0.0001 | Yes |
| Mandard | 144 | R | 281 | LN–, prem. | <0.001 | <0.001 | Yes |
| Manders | 145 | R | 137 | All | 0.0070 | 0.0017 | Yes |
| Page | 146 | R | 311 | LN– | NS | 0.01 | Yes |
| Pietilainen | 78 | R | 191 | All | – | 0.0025 | Yes |
| Russo | 90 | R | 646 | All | <0.0001 | – | Yes |
| Simpson | 147 | R | 560 | LN+ | 0.004 | – | Yes |
| Theissig | 148 | R | 92 | All | – | <0.0001 | Yes |
| Thor | 46 | R | 486 | All | 0.0056 | – | Yes |
| Toikkanen | 149 | R | 217 | Lobular | – | 0.0001 | Yes |
| Tosi | 150 | R | 350 | All | 0.025 | – | Yes |
| Uyterlinde | 115 | R | 63 | Ductal | – | 0.008 | Yes |
| 116 | R | 225 | Ductal | – | <0.0001 | Yes | |
| 117 | R | 295 | Ductal | – | <0.0001 | Yes | |
| Van Diest | 111 | R | 211 | <55 | – | <0.0001 | Yes |
| 110 | R | 20 | LN+ | – | 0.004 | – | |
| 9 | R | 148 | All | – | 0.0001 | Yes | |
| Younes | 151 | R | 300 | Ductal | – | 0.0032 | Yes |
