A patient with a VEGF and endostatin producing gastrointestinal autonomic nerve tumour
- A H G Hansma1,
- Y van Hensbergen1,
- B C Kuenen1,
- P J van Diest2,
- R Hanemaaijer4,
- S Meijer3,
- H M Pinedo1,
- K Hoekman1
- 1Department of Medical Oncology, Vrije Universiteit Medical Centre, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
- 2Department of Pathology, Vrije Universiteit Medical Centre
- 3Department of Surgery, Vrije Universiteit Medical Centre
- 4Gaubius Laboratory, TNO-PG, Leiden, The Netherlands
- Correspondence to: Dr K Hoekman Department of Medical Oncology, Vrije Universiteit Medical Centre, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands; k.hoekmanvumc.nl
- Accepted 21 October 2003
Abstract
Tumour associated neovascularisation has been characterised as chaotic and insufficient. This report details the results of the analysis of angiogenic factors in tumour cyst fluid, pleural fluid, and blood from a patient with a gastrointestinal autonomic nerve tumour. The tumour produced vascular endothelial growth factor and endostatin in large quantities, which may explain the dysfunctional angiogenesis and tendency to bleeding seen in this tumour type.
- bFGF, basic fibroblast growth factor
- ELISA, enzyme linked immunosorbent assay
- GANT, gastrointestinal autonomic nerve tumour
- MMP, matrix metalloprotease
- ms-mono, mouse monoclonal antibody
- NSE, neurone specific enolase
- PS, plasminogen activator
- STS, soft tissue sarcomas
- tPA, tissue plasminogen activator
- uPA, urokinase plasminogen activator
- VEGF, vascular endothelial growth factor
