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J Clin Pathol 2004;57:536-538 doi:10.1136/jcp.2003.012393
  • Case report

A patient with a VEGF and endostatin producing gastrointestinal autonomic nerve tumour

  1. A H G Hansma1,
  2. Y van Hensbergen1,
  3. B C Kuenen1,
  4. P J van Diest2,
  5. R Hanemaaijer4,
  6. S Meijer3,
  7. H M Pinedo1,
  8. K Hoekman1
  1. 1Department of Medical Oncology, Vrije Universiteit Medical Centre, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
  2. 2Department of Pathology, Vrije Universiteit Medical Centre
  3. 3Department of Surgery, Vrije Universiteit Medical Centre
  4. 4Gaubius Laboratory, TNO-PG, Leiden, The Netherlands
  1. Correspondence to:
 Dr K Hoekman
 Department of Medical Oncology, Vrije Universiteit Medical Centre, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands; k.hoekmanvumc.nl
  • Accepted 21 October 2003

Abstract

Tumour associated neovascularisation has been characterised as chaotic and insufficient. This report details the results of the analysis of angiogenic factors in tumour cyst fluid, pleural fluid, and blood from a patient with a gastrointestinal autonomic nerve tumour. The tumour produced vascular endothelial growth factor and endostatin in large quantities, which may explain the dysfunctional angiogenesis and tendency to bleeding seen in this tumour type.

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