Table 2
Relative VEGF-A mRNA expression determined by quantitative in situ hybridisation in different tumour types
| Tissue | Tumour type | VEGF-A phosphorimage volume (relative units) | U test | |||||
|---|---|---|---|---|---|---|---|---|
| HIF-1α positive | HIF-1α negative | |||||||
| N* | Median | IQR | N* | Median | IQR | |||
| *N, number of cores with number of cases in parentheses; †These p values are not considered significant by the false discovery rate controlling procedure,54 with a desired false discovery rate <0.05. | ||||||||
| HIF-1α, hypoxia inducible factor 1α; IQR, interquartile range; VEGF-A, vascular endothelial growth factor A. | ||||||||
| Adrenal | Carcinoma | 3 (1) | 26832 | 25861–27526 | 6 (2) | 40350 | 21383–62429 | 0.4386 |
| Breast | Ductal adenocarcinoma | 9 (7) | 6982 | 3448–8322 | 165 (78) | 6492 | 2759–10674 | 0.8651 |
| Endometrium | Adenocarcinoma | 0 | 6 (2) | 18942 | 5773–42790 | |||
| Kidney | Adenocarcinoma | 9 (3) | 194897 | 169937–263585 | 0 | |||
| Liver | Hepatocellular carcinoma | 2 (1) | 37978 | 22612–53344 | 6 (2) | 12847 | 8069–19191 | 0.0956 |
| Lung | Adenocarcinoma | 71 (30) | 40213 | 21246–67767 | 44 (21) | 24625 | 13594–53635 | 0.0394† |
| Neuroendocrine tumour | 0 | 15 (5) | 26564 | 20574–41287 | ||||
| Squamous cell carcinoma | 35 (17) | 41311 | 29085–72728 | 41 (18) | 40082 | 18356–76064 | 0.3842 | |
| Ovary | Adenocarcinoma | 3 (1) | 19842 | 17747–46596 | 3 (1) | 40991 | 29618–42359 | 0.5127 |
| Adenocarcinoma: endometrioid | 25 (14) | 20039 | 14073–40037 | 31 (15) | 16686 | 10488–39839 | 0.4633 | |
| Adenocarcinoma: serous | 18 (10) | 128343 | 38207–185213 | 55 (22) | 28502 | 19224–61354 | 0.0038 | |
| Adenocarcinoma: mucinous | 1 (1) | 5256 | 24 (12) | 4286 | 1785–6829 | 0.7815 | ||
| Adenocarcinoma: clear cell | 6 (3) | 117882 | 109480–136541 | 27 (10) | 35733 | 19849–107339 | 0.0842 | |
| Pancreas | Adenocarcinoma | 6 (3) | 18282 | 11131–33890 | 5 (2) | 35693 | 23563–44115 | 0.1003 |
| Soft tissue | Angiosarcoma | 4 (2) | 1490 | 743–10969 | 20 (7) | 504 | 269–2223 | 0.1879 |
| Fibrosarcoma | 0 | 11 (4) | 2394 | 1275–5204 | ||||
| Gastrointestinal stromal tumour | 1 (1) | 10779 | 16 (6) | 3678 | 1091–16290 | 0.4142 | ||
| Leiomyosarcoma | 4 (2) | 12920 | 2420–34709 | 14 (5) | 12097 | 10030–44381 | 0.3956 | |
| Liposarcoma | 3 (1) | 18772 | 12333–24699 | 25 (9) | 915 | 116–3224 | 0.0067 | |
| Malignant fibrous histiocytoma | 11 (5) | 9165 | 2893–12657 | 32 (13) | 6527 | 3195–11739 | 0.6361 | |
| Rhabdomyoscarcoma | 7 (3) | 13459 | 7475–73528 | 39 (15) | 2792 | 1423–5678 | 0.0011 | |
| Synovial sarcoma | 4 (2) | 13932 | 8009–35790 | 29 (11) | 4600 | 3096–8918 | 0.1856 | |
| Thyroid | Carcinoma | 38 (15) | 30073 | 22677–46610 | 72 (26) | 37024 | 21798–57202 | 0.2659 |
| Carcinoma: anaplastic | 3 (3) | 13371 | 13196–33180 | 3 (4) | 9073 | 5359–27547 | 0.3092 | |
| Carcinoma: medullary | 9 (3) | 29941 | 26268–143511 | 26 (9) | 17788 | 12459–45316 | 0.0326† | |
| Carcinoma: poorly differentiated | 11 (4) | 17925 | 15558–45240 | 11 (4) | 42054 | 26370–52769 | 0.1396 | |
| Adenocarcinoma: follicular | 9 (3) | 83909 | 52089–98721 | 0 | ||||
