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J Clin Pathol 57:388-393 doi:10.1136/jcp.2003.011841
  • Original article

The Dutch CISOE-A framework for cytology reporting increases efficacy of screening upon standardisation since 1996

Table 6

Age dependent effect of screening

⩽28 years 29–33 years 34–53 years 54–61 years ⩾ = 62 yrs All
Number of histological lesions detected for each 1000 cervical smears taken in the same calendar year, 1990–2000. Bold numbers indicate age categories invited for the population based screening programme.
*In 1996, the CISOE-A classification with formal reporting and referral was introduced and, in addition, three year interval screening for women 34–55 years was changed to five year interval screening for women 30–60 years; †p value for linear test for trend.
CIN, cervical intraepithelial neoplasia; SCC, squamous cell carcinoma.
CIN1 CIN2–3 SCC CIN1 CIN2–3 SCC CIN1 CIN2–3 SCC CIN1 CIN2–3 SCC CIN1 CIN2–3 SCC CIN1 CIN2–3 SCC
1990 3.4 5.2 0.1 3.5 6.4 0.2 3.1 1.2 0.3 2.8 1.1 1.3 3.7 1.4 5.4 3.2 4.1 0.4
1991 3.5 5.1 0.2 3.9 5.3 0.3 2.3 1.1 0.3 2.1 1.9 1.0 7.1 1.2 4.7 2.9 3.7 0.4
1992 3.9 5.0 0.1 4.6 7.8 0.4 3.8 1.1 0.6 4.3 3.1 0.4 4.3 1.3 5.4 3.9 5.0 0.6
1993 5.9 6.3 0.1 5.9 7.0 0.7 4.0 0.8 0.4 5.8 3.5 1.2 4.9 3.2 5.3 4.6 5.0 0.6
1994 5.8 6.4 0.1 6.2 8.0 0.3 3.3 0.5 0.3 3.2 1.9 0.7 3.3 4.0 7.0 4.1 4.5 0.5
1995 6.5 6.8 0.3 5.8 9.5 0.5 4.0 1.9 0.5 3.9 3.1 0.7 5.0 2.0 6.4 4.6 5.7 0.6
1996* 6.8 9.7 0.2 3.7 7.1 0.2 3.5 2.2 0.5 1.1 1.2 0.1 3.4 2.7 6.8 3.5 4.9 0.5
1997 8.4 11.5 0.3 5.2 10.1 0.4 4.2 4.4 0.4 1.6 1.9 0.1 2.5 0.8 5.9 4.2 6.1 0.4
1998 9.2 10.5 0.6 6.6 12.7 0.4 4.2 4.8 0.3 1.8 1.7 0.2 3.6 2.7 5.0 4.6 6.9 0.4
1999 8.5 8.5 0.0 5.0 14.2 0.5 3.9 4.0 0.5 1.7 1.5 0.0 4.2 4.2 2.8 4.0 6.7 0.4
2000 9.3 11.6 0.6 7.2 14.1 0.3 3.5 5.0 0.4 1.8 2.1 0.5 2.2 3.3 8.7 3.9 6.4 0.6
p Value† <0.001 <0.001 0.082 0.040 <0.001 0.569 0.080 0.003 0.449 0.101 0.531 0.008 0.057 0.096 0.610 0.180 <0.001 0.508

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