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J Clin Pathol 57:1292-1298 doi:10.1136/jcp.2003.015495
  • Original article

The perforin mediated apoptotic pathway in lung injury and fibrosis

Table 1

 Semiquantitative results of immunohistochemistry for perforin and granzyme B in IPF

Patient Perforin Granzyme B
Epi Fib Macro Lymph Epi Fib Macro Lymph
Grades of IPF: 0, no positive cells; 1, <10% of cells positive; 2, 10–49% of cells positive; 3, >50% of cells positive.
Epi, epithelium; Fib, fibroblast; IPF, idiopathic pulmonary fibrosis; Lymph, lymphocyte; Macro, macrophage.
IPF
    1 1 0 0 2 1 0 0 1
    2 1 1 0 3 1 1 1 1
    3 0 1 0 1 0 0 0 1
    4 1 0 0 3 1 1 0 3
    5 0 0 0 1 1 0 0 1
    6 1 1 0 2 1 1 0 2
    7 0 0 0 1 0 0 0 2
    8 0 0 0 2 0 0 0 2
Controls
    1 0 0 0 0 0 0 0 0
    2 0 0 0 0 0 0 0 0
    3 0 0 0 0 0 0 0 0
    4 0 0 0 0 0 0 0 0
    5 0 0 0 0 0 0 0 0

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