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J Clin Pathol 57:1245-1249 doi:10.1136/jcp.2004.018952
  • Review

Aneuploidy and malignancy: an unsolved equation

Table 1

 Aneuploidy in different malignancies

Malignancy Chromosomal alteration
Acute myeloid leukaemia3 Gain of chromosome 8 (13%) and loss of chromosome 7 (10%)
Chronic lymphocytic leukaemia4 Trisomy 12 (30%)
Acute lymphatic leukaemia5 Gain of chromosomes 4, 6, 10, 14, 17, 18, 20
Non-Hodgkin lymphoma6 Trisomy 12
Bladder carcinoma6 Trisomy 7, monosomy 8
Malignant fibrous histiocytoma6 Gain of chromosome 19
Lung carcinoma7 Loss of Y chromosome and gain of chromosome 7
Breast carcinoma8 Trisomy 7, 8, 18, 20
Uterine carcinoma9,10 Diploid range, trisomy 10, gain of chromosomes 2, 7, 12
Ovarian carcinoma11 Loss of chromosomes 22, 17, 13, 14, 8 and gain of chromosome 22
Prostatic carcinoma12,13 Normal karyotype, loss of Y chromosome and gain of chromosomes 7, 14, 3
Colonic carcinoma14 Gain of chromosomes 3, 4, 6, 11, 12, 13, 15, 16
Loss of chromosomes 14, 15, 18

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