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J Clin Pathol 57:1156-1159 doi:10.1136/jcp.2004.018150
  • Original article

The metabolic marker tumour pyruvate kinase type M2 (tumour M2-PK) shows increased expression along the metaplasia–dysplasia–adenocarcinoma sequence in Barrett’s oesophagus

Table 1

 Tumour pyruvate kinase type M2 (M2-PK) staining in reflux oesophagitis, Barrett’s metaplasia, Barrett’s dysplasia, oesophageal adenocarcinoma, and colorectal adenocarcinoma

Tissue type (number of cases) Staining intensity (cytoplasmic) Proportion of cells positive %
0 + ++ 0 <30 30–60 >60 100
Reflux oesophagitis (17) 0 0 17 Lower 1/3–1/2 of mucosa
Barrett’s metaplasia (37) 0 0 37 0 5 13 16 3
Barrett’s dysplasia (21) 0 0 21 0 0 2 19 0
Adenocarcinoma (112) 0 0 112 0 0 0 0 112
Control tumours (3) 0 0 3 0 0 0 0 3

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