Table 5
Prothrombin complex concentrates available in the UK
| Product | Manufacturer | Virus inactivation | Coagulation factor composition* (IU) | ||||
|---|---|---|---|---|---|---|---|
| II | VII | IX | X | Protein C (IU) | |||
| *Coagulation factor and protein C composition in a single vial (information from product data sheets produced by manufacturers). | |||||||
| BPL, Bioproducts Ltd; SNBTS, Scottish National Blood Transfusion Service. | |||||||
| HTDEFIX | SNBTS, Edinburgh, UK | 80°C for 72 hours | >200 | 0 | >300 | >200 | Not stated |
| Terminal dry heat | |||||||
| Prothromplex T | Baxter, Vienna, Austria | 60°C for 10 hours and 80°C for 1 hour | 600 | 500 | 600 | 600 | >400 |
| Vapour heating | |||||||
| Beriplex P | Aventis, ZLB Behring, Marburg, Germany | 60°C for 10 hours and nanofiltration | 400–960 | 200–500 | 400–620 | 440–1200 | 300–900 |
| Octaplex | Octapharma, Vienna, Austria | Solvent detergent and nanofiltration | 220–760 | 180–480 | 500 | 360–600 | 140–620 |
