Table 2
Homocysteine and vitamin status in patients with stroke who have different MTHFR genotypes after excluding patients taking vitamin supplements
| Variable | Genotype (three categories) | Genotype (two categories) | |||||
|---|---|---|---|---|---|---|---|
| CC (N = 21) | CT (N = 24) | TT (N = 4) | p Value (ANOVA) | CC/CT (N = 45) | TT (N = 4) | p Value (ANOVA) | |
| N5MTHF, N5-methyltetrahydrofolate; MTHFR, N5N10-methylenetetrahydrofolate reductase. | |||||||
| Plasma homocysteine (μmol/l) | 13.9 | 11.5 | 12.6 | 0.17 | 12.4 | 12.6 | 0.96 |
| Serum B6 (nmol/l) | 31.5 | 37.3 | 32.1 | 0.50 | 34.8 | 32.1 | 0.77 |
| Serum cobalamin (pmol/l) | 419.9 | 376.2 | 528.5 | 0.21 | 395.4 | 528.5 | 0.14 |
| Total red cell folate (nmol/l) | 645.5 | 589.9 | 273.1 | 0.02 | 614.0 | 273.1 | 0.01 |
| Red cell N5MTHF (nmol/l) | 614.0 | 566.8 | 252.1 | 0.02 | 589.9 | 252.1 | <0.01 |
| Serum folate (nmol/l) | 12.2 | 18.2 | 9.2 | 0.12 | 15.0 | 9.2 | 0.23 |
| Serum N5MTHF (nmol/l) | 12.1 | 17.3 | 9.1 | 0.16 | 14.6 | 9.1 | 0.26 |
| “Immunoassay” red cell folate (nmol/l) | 727.8 | 888.9 | 658.5 | 0.32 | 812.4 | 658.5 | 0.43 |
