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J Clin Pathol 2003;56:579-582 doi:10.1136/jcp.56.8.579
  • Original article

Prognostic significance of grading (MIB-1 system) in patients with myxoid liposarcoma

  1. U Tateishi1,
  2. T Hasegawa2,
  3. Y Beppu3,
  4. A Kawai3,
  5. N Moriyama1
  1. 1Division of Diagnostic Radiology, National Cancer Centre Hospital, Tsukiji, Chuo-Ku, 104–0045, Tokyo, Japan
  2. 2Division of Pathology, National Cancer Centre Hospital
  3. 3Division of Orthopaedics, National Cancer Centre Hospital
  1. Correspondence to:
 Dr U Tateishi, Division of Diagnostic Radiology, National Cancer Centre Hospital, Tsukiji, Chuo-Ku, 104–0045, Tokyo, Japan; 
 utateish{at}ncc.go.jp
  • Accepted 25 February 2003

Abstract

Aims: To determine the relation between clinical outcome and tumour grade defined by a MIB-1 (Ki-67) score based grading system.

Method: The clinical and pathological features of 50 patients with myxoid liposarcoma were evaluated, and MIB-1 immunostaining was performed to grade these patients’ tumours. Univariate and multivariate analyses were conducted to evaluate survival. Clinical follow up details were available for all patients (median, 46.5 months; range, 9–408).

Results: Univariate analysis revealed that the tumour site (p < 0.05), round cell component content (p < 0.01), necrosis (p < 0.01), mitosis (p < 0.01), MIB-1 labelling index (p < 0.001), and tumour grade (p < 0.001) had a significant impact on overall survival. Multivariate analysis showed that, of the variables evaluated, the tumour grade defined by a MIB-1 score based grading system was the most significant adverse prognostic factor.

Conclusion: Tumour grade determined by the grading system using the MIB-1 score (MIB-1 system) is a very strong prognostic factor in patients with myxoid liposarcoma.

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