Clear cell carcinoma of the breast with solid papillary pattern: a case report with immunohistochemical profile
- Correspondence to: Dr S K Özkara, Mustafa Pasa Mahallesi, Bagdat Caddesi, 0712. Sokak, No: 19/6, 41400, Gebze, Kocaeli, Turkey; Erkacar{at}sisecam.com.tr
- Accepted 28 January 2003
Abstract
Glycogen rich clear cell carcinoma of the breast is a rare neoplasm with different morphological characteristics to ordinary breast carcinomas. However, it has some common features with clear cell carcinomas of other organs. This report describes a case of clear cell carcinoma of the breast with a solid papillary pattern centrally localised in the left breast of a 45 year old woman. Antibodies directed against cytokeratin 7 (CK7), CK10, CK14, CK17, CK18, CK19, CK20, CK5/6/18, CK8/18, high molecular weight cytokeratin AE3, high molecular weight cytokeratin 34βE12, the oestrogen receptor, the progesterone receptor, chromogranin, S-100 protein, smooth muscle actin, vimentin, and carcinoembryogenic antigen were applied to analyse the immunophenotypical profile of this rare neoplasm.
- CCC, clear cell carcinoma
- CEA, carcinoembryogenic antigen
- CK, cytokeratin
- CR, chromogranin
- ER, oestrogen receptor
- HMWCK, high molecular weight cytokeratin
- PAS, periodic acid Schiff
- PR, progesterone receptor
- RCC, renal cell carcinoma
- SMA, smooth muscle actin
