Pathogenesis of systemic lupus erythematosus

Table 6

Environmental factors that may be relevant in the pathogenesis of systemic lupus erythematosus

Chemical/physical factors

Aromatic amines
Hydrazines
Drugs (procainamide, hydralazine, chlorpromazine, isoniazid, phenytoin, penicillamine)
Tobacco smoke
Hair dyes
Ultraviolet light

Dietary factors

L-canavanine (alfalfa sprouts)
High intake of saturated fats

Infectious agents

?Bacterial DNA/endotoxins
?Retroviruses

Hormones and environmental oestrogens

Hormonal replacement therapy, oral contraceptive pills
?Prenatal exposure to oestrogens

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Pathogenesis of systemic lupus erythematosus

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