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J Clin Pathol 56:417-422 doi:10.1136/jcp.56.6.417
  • Review

The immunopathogenesis of meningococcal disease

Table 1

Characteristic features of meningococcal disease in patients with complement deficiency

Feature Comment
A finding of any of these features should prompt testing of complement function.
Unusual serogroup Infection with an unusual serogroup organism such as W135 is strongly suggestive of complement deficiency
Recurrent disease This seems to be particularly associated with terminal complement component deficiency
Family history Complement deficiency inheritance is usually autosomal recessive or X linked (see text)

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