Table 2
α-Methylacyl CoA racemase (AMACR/P504S) immunohistochemical staining of prostate needle biopsies: summary of published data
| First author | Antibody used | Number of biopsies (malignant/benign) | Malignant foci with positive staining | Benign foci with positive staining* |
|---|---|---|---|---|
| *Includes normal, hyperplastic, and atrophic glandular epithelium and excludes high grade prostatic intraepithelial neoplasia; †7 biopsies with foci of adenocarcinoma <1 mm in maximum dimension; all 7 showed positive AMACR/P504S staining; ‡26/70 biopsies had foci of adenocarcinoma requiring 34βE12 to support a malignant diagnosis; §all 73 biopsies had foci of adenocarcinoma <1 mm in maximum dimension supported by confirmatory 34βE12 staining. | ||||
| Jiang21 | Rabbit monoclonal anti-P504S (Abgenix Biopharma, Vancouver, Canada) | 112 (58/54) | 58/58† | 8/54 |
| Rubin8 | Polyclonal anti-AMACR (gift from Dr R Wanders) | 94 (70/24) | 68/70‡ | 0/24 |
| Jiang18 | Rabbit monoclonal anti-P504S | 142 (73§/69) | 69/73 (95%) | 0/69 (0%) |
| Beach19 | Rabbit monoclonal anti-P504S (clone 13H4) | 376 (186,190) | 153/186 (82%) | 81/377 (21%) |
