rss
J Clin Pathol 2003;56:798-800 doi:10.1136/jcp.56.10.798
  • Case report

Insertion of the CCND1 gene into the IgH locus in a case of leukaemic small cell mantle lymphoma with normal chromosomes 11 and 14

  1. A Aventín1,
  2. J Nomdedéu1,
  3. J Briones1,
  4. I Espinosa2,
  5. R Bordes2,
  6. J Sierra1
  1. 1Department of Haematology, Hospital Sant Pau, 08025 Barcelona, Spain
  2. 2Department of Pathology, Hospital Sant Pau
  1. Correspondence to:
 Dr A Aventín, Department of Haematology, Hospital Sant Pau, Avda. Sant Antoni Ma Claret, 167, 08025 Barcelona, Spain;
 aaventin{at}hsp.santpau.es
  • Accepted 13 May 2003

Abstract

The t(11;14)(q13;q32) translocation is considered to be the cytogenetic hallmark of mantle cell lymphoma. This report describes a case of leukaemic mantle cell lymphoma in which conventional cytogenetics on stimulated peripheral blood cells showed a 46,XY, t(1;12)(p21;q23)/46,XY karyotype. Fluorescence in situ hybridisation analysis using a dual colour immunoglobulin heavy chain (IgH)/CCND1 probe showed a fusion hybridisation signal on one normal chromosome 14, indicating that an insertion of the CCND1 gene into the 14q32/IgH locus had taken place. Overexpression of the cyclin D1 protein was demonstrated on bone marrow trephine by immunohistochemical staining.

Footnotes

    This Article

    Services

    1. Request permissions

    Responses

    1. Submit a response
    2. No responses published

    Social bookmarking

    Latest from JCP Education

    Latest from JCP Education

    Register for free content


    Free sample
    This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of JCP.
    View free sample issue >>

    Free archive
    The full back archive is now available for JCP. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006, back to volume 1 issue 1.
    Register to access the free archive >>

    Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

  • Latest Pathology jobs

    Latest Pathology jobs